Pathophysiology of Myelodysplastic Syndromes
Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes.Its pathophysiology relies on a diversity of mechanisms supported by genetic m&m speckled eggs events that develop in aging hematopoietic stem cells.Deletion and mutations trigger epigenetic modifications, and co-transcriptional and post-transcriptional deregul